After completing her MA in international development management, Audette-Nikoli worked in the Occupied Palestinian Territories as a manager for a multimillion-dollar World Bank-funded project to encourage nonviolence and positive expressions of civic feeling among Palestinian youth. She later joined World Vision International, where she spearheaded efforts to design and monitor development projects in the areas of education, psychosocial well-being, advocacy, agriculture and economic development. After three years in the Palestinian Territories, she moved to Sierra Leone to continue her work. Audette-Nikoli is part of World Vision's network of international trainers in her area of work.

Audette-Nikoli's research with children affected by armed conflicts has been used by World Vision as part of advocacy campaigns in the United States and United Kingdom, and her written work about her experiences in the Middle East has been featured in numerous newspapers and Web sites in the U.S., U.K., and Australia.